Neonatal Urine Metabolic Signature Reflects Multisystemic Adaptations Linked to Preterm Birth.

ABSTRACT: Prematurity is associated with a higher risk of developing short- and long-term metabolic complications. However, the concrete mechanisms are not yet fully understood. The purpose of this study was to characterize early urinary metabolic adaptations linked to preterm birth. Urine samples collected at one month of age were compared between extremely and very preterm neonates (<32 weeks gestation) (n = 45) and term newborns (n = 96). Liquid chromatography coupled to mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) techniques were both applied and analyzed independently. Univariate analysis and multivariate analyses were utilized to assess the impact of preterm birth on the metabolites identified. Multiblock analysis was further used to evaluate the effect of prema

SUBMITTER: Bibiloni P 

PROVIDER: S-EPMC12469547 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature