Preparation of Curcumin Nanocomposite Drug Delivery System and Its Therapeutic Efficacy on Skin Injury.

ABSTRACT: Background: Skin injuries, such as chronic wounds and inflammatory skin diseases, often face limitations in treatment efficacy due to the low efficiency of transdermal drug delivery and insufficient local concentrations. Curcumin (CUR), a natural compound with anti-inflammatory and antioxidant properties, has demonstrated potential in the repair of skin damage; however, its clinical application is hindered by its physicochemical characteristics. This study constructs a novel nanocomposite drug delivery system: CUR-loaded micellar nanocomposite gel (CUR-M-DMNs-Gel). A composite system is used to achieve the efficient solubilization and enhanced transdermal permeation of CUR, thereby providing a novel formulation approach for the treatment of skin diseases. Methods:</

SUBMITTER: Jin Y 

PROVIDER: S-EPMC12469627 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature