Sedentary Duration and Systemic Health Burden: Nonlinear Associations with Muscle, Fat, and Vascular Phenotypes in a US Population-Based Study.

ABSTRACT: Background: Sedentary behavior (SB) is a growing public health concern associated with cardiometabolic risk; yet few studies have assessed integrated physiological responses across the muscle-fat-vascular system. Methods: This retrospective cross-sectional analysis used data from 13,637 participants (≥12 years) in the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Sedentary duration (SD) was self-reported via a validated questionnaire. Outcomes included the sarcopenic index (SI), fat distribution index (FDI), and pulse pressure index (PPI). Associations were examined using multivariable linear regression and restricted cubic spline models, adjusting for sociodemographic and lifestyle factors. Subgroup analyses explored effect modification by body mass in

SUBMITTER: Hu C 

PROVIDER: S-EPMC12469714 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature