Effect of Tigecycline on the Homeostasis of Human Epidermal Melanocytes and Fibroblasts.

ABSTRACT: Tigecycline is an antibiotic belonging to the glycylcycline group of tetracyclines. Similar to other tetracycline derivatives, tigecycline is used in dermatology because of its bacteriostatic effect. Despite an overall favorable safety profile, tetracyclines are associated with a spectrum of cutaneous adverse effects, notably pigmentary disorders and phototoxic reactions. These dermatologic manifestations are presumed to result from tigecycline's affinity for melanin biopolymer and its subsequent accumulation within the pigment-containing tissues. This study aimed to assess the impact of tigecycline on human normal skin cell homeostasis varied by melanin content. The study was conducted on HEMn-LP melanocytes and human dermal fibroblasts. The aim was achieved by determining the cell number

SUBMITTER: Rzepka Z 

PROVIDER: S-EPMC12469777 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature