Genes Encoding Heat Shock Proteins Are Associated with Risk and Clinical Course of Severe COVID-19: A Pilot Study.

ABSTRACT: In viral infections human heat shock proteins (HSPs) play a dual role by either protecting host cells or acting on viruses' needs. The roles of HSPs have been extensively studied in various human pathologies, but their involvement in the progression of COVID-19 remains unexplored. It makes HSPs genetic variants particularly interesting in the context of severe COVID-19 risk. In this study, 1228 subjects (199 hospitalized COVID-19 patients and 962 controls) were genotyped for 20 SNPs in genes encoding HSPs and their regulators. SNP rs7189628 DNAJA2 (effect allele [EA] T) increased the risk of severe COVID-19 in the entire group (p = 0.002), males (p = 0.00008), and smokers (p = 0.0003). SNP rs910652 HSPA12B (EA C) decreased the risk of severe COVID-

SUBMITTER: Karpenko AR 

PROVIDER: S-EPMC12469910 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature