Stutter Modeling in Probabilistic Genotyping for Forensic DNA Analysis: A Casework-Driven Assessment.

ABSTRACT: Background: Probabilistic genotyping software has become an essential tool in forensic genetics, particularly for interpreting complex DNA mixtures. Previous studies measured the impact of considering widely divergent statistical approaches in quantifying evidence, both inter- and intra-software. At a much smaller scale, this data-driven study shows how different models implemented on distinct versions of the same tool may affect the results. Among the available tools, EuroForMix stands out as a quantitative, open-source software that models various aspects of the DNA profile, including artefacts like stutter peaks. Its freeware nature allowed the use of both versions 1.9.3. and 3.4.0, between which several updates were made, including the possibility to model both back and forward

SUBMITTER: Costa C 

PROVIDER: S-EPMC12469979 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature