Indole-Pyrazole Hybrids: Synthesis, Structure, and Assessment of Their Hemolytic and Cytoprotective Properties.

ABSTRACT: In recent years, we have observed a growing interest in molecular hybridization, which involves combining chemically and pharmacologically diverse fragments into a single molecule. In this study, we designed and synthesized a series of indole-pyrazole hybrids, variously substituted at the pyrazole ring. The compounds were characterized by spectroscopic methods, and the structures of most of them were confirmed by X-ray analysis. Reactions of 3-(dimethylaminomethyl)indole with bromo-methyl-pyrazole derivatives proceeded in a tautomer-selective mode: the 4-bromo-3(5)-methyl-((1H-pyrazol-1-yl)methyl)-1H-indole tautomers, obtained from the 4-bromo-3-methyl-1H-pyrazole, could be isolated by column chromatography. In contrast, the 3-bromo-5-methyl-1H-pyrazole yielded

SUBMITTER: Babijczuk K 

PROVIDER: S-EPMC12470152 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature