Genetic and Epigenetic Factors in Ulcerative Colitis: A Narrative Literature Review.

ABSTRACT:

Background/objectives

Ulcerative colitis is a chronic inflammatory bowel disease whose incidence is steadily growing worldwide. The interactions between host genetic susceptibility, gut microbiota and environmental factors determine the onset and relapsing evolution of ulcerative colitis, making it a multifactorial disorder.

Methods

A narrative review was conducted to synthesize the available literature on the genes and mechanisms related to ulcerative colitis.

Results

The most important independent risk factor is genetics and the candidate genes are associated with inflammation, immune regulation and epithelial permeability. Multiple GWAS have already identified candidate genes and their polymorphisms implicated in ulcerative colitis pathogenesis. Genetic susceptibil

SUBMITTER: Caba L 

PROVIDER: S-EPMC12470167 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature