Identification of Novel Gene Cluster Potentially Associated with Insecticide Resistance in <i>Anopheles gambiae</i> s.l.

ABSTRACT:

Background/objectives

Despite the increasing emergence of resistance, insecticide-based tools remain the primary method for malaria vector control in Africa. To maintain the effectiveness of these interventions, continuous monitoring and identification of novel resistance mechanisms is essential. This study aimed to investigate potential new insecticide resistance genes in the Anopheles gambiae complex.

Methods

We analyzed whole-genome sequencing data from the An. gambiae 1000 Genomes Project. A broad range of genomic analysis techniques and tools were used to identify and explore genetic variation in the candidate resistance genes.

Results

High haplotype homozygosity values, indicative of positive selection, were detected in a 2L chromosomal region corr

SUBMITTER: Ki HD 

PROVIDER: S-EPMC12470184 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature