Comprehensive Profiling Identifies Circulating microRNA Dysregulation in Vietnamese Patients with Heart Failure.

ABSTRACT: Heart failure (HF) is a complex and multifactorial syndrome with high morbidity and mortality rates worldwide. Accumulative evidence suggests that microRNAs (miRNAs) play critical roles in maintaining cardiac homeostasis. The dysregulation of various miRNAs has been reported in different studies on failing human hearts. However, little is known about their circulatory profile. In this study, comprehensive miRNA profiling was performed by next-generation sequencing for plasma samples of 24 HF and 24 age and sex-matched, non-HF patients. A total of 1391 miRNAs were detected, of which 228 miRNAs and 261 miRNAs were commonly expressed in the HF and non-HF groups, respectively. Eight miRNAs (hsa-let-7b-3p, hsa-miR-92b-5p, hsa-miR-145-3p, hsa-miR-206, hsa-miR-664a-5p, hsa-miR-1307-5p, hsa-miR-19

SUBMITTER: Vu BQ 

PROVIDER: S-EPMC12470235 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature