Investigating the Development of Colorectal Cancer Based on Spatial Transcriptomics.

ABSTRACT: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. However, the spatial and temporal dynamics underlying its development remain poorly characterized. This study employs spatial transcriptomics (ST) to investigate the progression of intestinal tumors in APC ^Min/+ mice across multiple time points. We identified distinct transcriptional profiles between tumor and normal tissues, resolving six major cell types through integrated dimensionality reduction and pathological annotation. Pseudo-time trajectory analysis revealed increased expression of MMP11 and MYL9 in later stages of tumor progression. Analysis of human CRC cohorts from the TCGA database further confirmed that high expression of these genes is associated with advan

SUBMITTER: Qi Z 

PROVIDER: S-EPMC12470395 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature