Does the Vaginal Microbiota Influence the Incidence of the Preterm Premature Rupture of Membranes?

ABSTRACT: Introduction: The study aimed to provide a systematic review and analysis of previously reported studies investigating the association between the bacterial microbiome and the incidence of preterm premature rupture of membranes (PPROM). Material and Methods: A comprehensive literature search across many databases via 01 March 2023, including PubMed, Web of Science, Embase, and the Cochrane Library. Results: A total of 20 studies were reviewed, all of which provided a comprehensive analysis of the microbial makeup in pregnant women. The findings suggest that disturbances in the bacterial microflora correlate with a heightened risk of PPROM. Conclusions: There was a significant reduction of naturally prevalent vaginal species (in the vaginal flora of women with PP

SUBMITTER: Feduniw S 

PROVIDER: S-EPMC12470435 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature