Purified Native Collagen Extracellular Matrix Plus Polyhexamethylene Biguanide Functions as a Barrier to Protect Complex Wounds in an In Vivo Model.

ABSTRACT: Complex surgical wounds often necessitate repeated irrigation and debridement (I&D), resulting in substantial burdens. Purified native collagen extracellular matrix plus polyhexamethylene biguanide (PCMP) is a protective antimicrobial barrier that supports innate wound healing and was hypothesized to protect an in vivo complex wound. Canines underwent bilateral fibular defects, which were stabilized using screws and plates pre-incubated with methicillin-resistant Staphylococcus aureus. Wounds were clinically infected seven days post-op and underwent I&D prior to application with either PCMP or non-adherent pads. Outcome assessments included radiography, wound scoring, microbial culture, histology, and gene expression. PCMP application resulted in significantly improved clinical woun

SUBMITTER: Nasrallah RA 

PROVIDER: S-EPMC12470437 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature