Recurrent Duplication, Testis-Biased Expression, and Functional Diversification of <i>Esf2/ABT1</i> Family Genes in <i>Drosophila</i>.

ABSTRACT: Gene duplications are considered to be the major evolutionary resource of novel functions. The gene family Esf2/ABP1 is conserved in metazoan organisms from yeast to humans. Here we performed a search and characterization of Esf2/ABP1 homologs in the Drosophila genus. Whereas in the majority of Drosophila species this gene family is represented by only a single gene, in the melanogaster and suzukii subgroups recurrent gene duplications arose, providing 47 homologous genes located on the X chromosome. To study the evolutionary history of duplicates, we performed phylogenetic, functional domain, and tissue-specific expression analyses. We revealed a male-specific and testis-biased transcription pattern of duplicated copies in Drosophila melanogast

SUBMITTER: Davydova ED 

PROVIDER: S-EPMC12470439 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature