Intracranial Metastases from Uterine Leiomyosarcoma: A Systematic Review and Case Illustration.

ABSTRACT: Background/Objectives: Brain metastasis from uterine leiomyosarcoma (ULMS) is an exceptionally rare complication of an aggressive malignancy. With fewer than 40 cases previously documented, a significant knowledge gap exists regarding its clinical course, management, and outcomes. This study provides the largest analysis of ULMS brain metastases to date, integrating a systematic literature review with a novel case report illustrating the disease's uniquely rapid progression. Methods: Following PRISMA guidelines, we systematically reviewed four major databases to identify all reported cases of intracranial metastasis from ULMS. Data on patient demographics, clinico-radiological features, treatments, and survival were extracted and analyzed. Methodological quality was assessed

SUBMITTER: Pour-Rashidi A 

PROVIDER: S-EPMC12470581 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature