National Belgian Study on Terbinafine Resistance in <i>Trichophyton interdigitale/mentagrophytes/indotineae</i> (2022-2023): Epidemiology and Molecular Features.

ABSTRACT: Objectives: Trichophyton indotineae, a dermatophyte closely related to T. interdigitale and T. mentagrophytes, is of growing concern due to its high terbinafine resistance and widespread presence in India. Its emergence in Europe calls for enhanced surveillance. Resistance is linked to mutations in the squalene epoxidase (SQLE) gene. This multicentric national study aimed to evaluate the prevalence, terbinafine susceptibility, and phylogenomics of T. interdigitale/mentagrophytes/indotineae strains in Belgium, with a focus on SQLE substitutions. Methods: Between February 2022 and April 2023, 137 isolates from 16 Belgian labs were analyzed for antifungal susceptibility using the EUCAST E.Def.11.0 method. Whole-genome sequencing (WGS) was perfo

SUBMITTER: Sacheli R 

PROVIDER: S-EPMC12470705 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature