Evaluation of the Sphingolipidomic Profile in Women with Anorexia Nervosa: Relationships with Parameters Related to Body Composition, Cardiovascular Function, Glucometabolic Homeostasis, and Lipoprotein Metabolism.

ABSTRACT: Background. Anorexia nervosa (AN) is a metabolic-psychiatric disease, in which, besides an extremely low body weight, there is a paradoxical dyslipidemia. Objectives. The aims of the present study were (1) to carry out a sphingolipidomic profiling in a group of women with AN (n = 28; body mass index [BMI]: 15.54 [13.96-16.32] kg/m²) compared to a normal-weight healthy (NWH) group (n = 30; BMI: 22.05 [19.67-23.72] kg/m²), and (2) to correlate plasma levels of single or total sphingolipids with parameters related to body composition, cardiovascular function, glucometabolic homeostasis, and lipoprotein metabolism. Results. Age, weight, BMI, fat mass (FM) (%), and fat-free mass (FFM) (kg) were significantly lower in women with AN than in the NWH group

SUBMITTER: Rigamonti AE 

PROVIDER: S-EPMC12470723 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature