Ginkgo Seed as Medicine-Food Homology for Migraine: Network Pharmacology and Molecular Docking Insights.

ABSTRACT: As a medicinal and edible homologous substance, ginkgo seeds' historical application in headache management, documented from Diannan Materia Medica to contemporary clinical practice, is based on empirical evidence. This study employed network pharmacology and molecular docking to explore the anti-migraine mechanisms of ginkgo seeds. In total, 10 related signal pathways (cancer pathway, lipid and atherosclerosis, Phosphatidylinositol 3-Kinase-Protein Kinase B (PI3K-AKT) signaling pathway, etc.) and 10 hub genes were identified through Gene Ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and in the inprotein-protein interaction (PPI) network. Molecular docking results demonstrated that formononetin, stigmasterol, and beta-

SUBMITTER: Li Z 

PROVIDER: S-EPMC12470726 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature