SERCA Silencing Alleviates Aß_(1-42)-Induced Toxicity in a <i>C. elegans</i> Model.

ABSTRACT: The Sarco Endoplasmic Reticulum Ca²⁺-ATPase (SERCA) pumps cytosolic Ca²⁺ into the endoplasmic reticulum lumen (ER) to maintain cytosolic and ER Ca²⁺ levels under physiological conditions. Previous reports suggest that cellular Ca²⁺ homeostasis is compromised in Alzheimer's Disease (AD) and that SERCA activity can modulate the phenotype of AD mouse models. Here, we used a C. elegans strain that overexpresses the most toxic human ß-amyloid peptide (Aß_(1-42)) in body-wall muscle cells to study the effects of SERCA (sca-1) silencing on Aß_(1-42)-induced body-wall muscle dysfunction. sca-1 knockdown reduced the percentage of paralyzed worms, improved locomotion in free-mobility assays, and restored pharynx pum

SUBMITTER: Caldero-Escudero E 

PROVIDER: S-EPMC12470765 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature