<i>Mentha rotundifolia</i>, a Source of Amoebicidal Agents Against <i>Naegleria fowleri</i>.

ABSTRACT: Current therapies for Primary Amoebic Meningoencephalitis (PAM) present several limitations; consequently, there is an urgent need to develop new therapeutic agents. In this regard, we undertook bioassay-guided isolation of Mentha rotundifolia leaves which allowed the identification of ursolic acid (1) as the main bioactive metabolite against two ATCC strains of Naegleria fowleri (ATCC^® 30808^TM and ATCC^® 30215^TM). Moreover, ten ursolic acid derivatives (2-11) were synthesized through esterification and nucleophilic substitution to obtain halo or amino ester derivatives. Among these derivatives, compound 7 exhibited the highest activity against the N. fowleri ATCC^® 30808^TM stra

SUBMITTER: Ben Youssef M 

PROVIDER: S-EPMC12470768 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature