Properties of Putative APSES Transcription Factor AfpA in <i>Aspergillus fumigatus</i>.

ABSTRACT: Aspergillus fumigatus is a major opportunistic pathogenic fungus that causes invasive aspergillosis with high mortality rates in immunocompromised patients. APSES family transcription factors regulate fungal development and virulence, but the function of the putative APSES-type transcription factor AfpA (AFUA_5g11390) remains uncharacterized. To investigate the roles of AfpA in A. fumigatus, we constructed the ΔafpA mutant and performed phenotypic analyses, RT-qPCR analyses, and virulence studies. The ΔafpA mutant exhibited reduced vegetative growth but increased conidiation, with upregulation of asexual developmental regulators brlA, abaA, and wetA. AfpA positively regulated cAMP-PKA signaling, resulting in delayed conidia germinatio

SUBMITTER: Choi YH 

PROVIDER: S-EPMC12470788 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature