<i>Pneumocystis jirovecii</i> Pneumonia Diagnosis with Oropharyngeal Wash PCR in Immunocompromised Patients-A Systematic Review.

ABSTRACT: Background/Objectives:Pneumocystis jirovecii pneumonia (PJP) remains a major cause of morbidity and mortality in immunocompromised patients. Bronchoalveolar lavage (BAL) is the diagnostic gold standard but is invasive and often impractical in critically ill patients. Oropharyngeal wash (OW) polymerase chain reaction (PCR) offers a rapid, non-invasive alternative. We performed a systematic review focusing on this respiratory sample's diagnostic accuracy and clinical utility. Methods: We searched PubMed, Scopus, Web of Science, Cochrane Library, and clinical trial registries including ClinicalTrials.gov and MedRxiv for studies of PCR-based P. jirovecii detection in OW samples from immunocompromised adults, using BAL or induced sputum as reference standards. The Pr

SUBMITTER: Costa VS 

PROVIDER: S-EPMC12470813 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature