Remodeling of Gut Microbial Networks After Sulforaphane Supplementation in Patients with Chronic Kidney Disease.

ABSTRACT:

Background and objectives

Chronic kidney disease (CKD) is closely associated with gut dysbiosis, and sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, may help to mitigate this condition.

Methods

These are secondary exploratory analyses from a previous study that included 16 patients with CKD (stages 3 to 5). The patients were divided into two groups: the Sulforaphane (SFN) group (400 mcg/day of SFN) and the placebo group, both of which received treatment for four weeks. Fecal DNA extraction was performed, and amplicon sequencing was conducted on an Illumina MiSeq V3 platform. The sequence data were analyzed using the QIIME 2 software package. Plasma uremic toxin concentrations (indoxyl sulfate, IS, and p-cresyl sulfate, pCS) were measured by HPLC wit

SUBMITTER: Ribeiro M 

PROVIDER: S-EPMC12470981 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature