Murine Cell Line Models for Vascular Mimicry: The Role of YAP/TAZ Signaling.

ABSTRACT: Vascular mimicry (VM) refers to the formation of vessel-like structures by tumor cells independent of endothelial cells. These VM channels connect to the host's vascular network and are associated with aggressive tumors and poor patient prognosis. Most VM research has been conducted on melanoma, relying on patient-derived and mouse cell lines. In other solid tumors, VM studies rely on human cell lines, which have certain limitations for in vivo studies. Specifically, most in vivo VM research involving human cells uses subcutaneous mouse models that fail to recapitulate organ-specific tumor microenvironments. As the microenvironment is an essential driver of tumor vascularization, including VM, murine cell lines could facilitate VM investigations in syngeneic mouse models. Here, we present

SUBMITTER: Righetti M 

PROVIDER: S-EPMC12471087 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature