Discovery of Undescribed Clerodane Diterpenoids with Antimicrobial Activity Isolated from the Roots of <i>Solidago gigantea</i> Ait.

ABSTRACT: Three previously undescribed clerodane diterpenoids, including two cis-clerodanes, solidagolactone IX (1) and solidagoic acid K (2), and one trans-clerodane, solidagodiol (3), along with two known cis-clerodane diterpenoids, (-)-(5R,8R,9R,10S)-15,16-epoxy-ent-neo-cleroda-3,13,14-trien-18-ol (4) and solidagoic acid J (5), were isolated and comprehensively characterized from the ethanolic and ethyl acetate root extract of Solidago gigantea Ait. (giant goldenrod). Compound 4 has previously been reported from the roots of this species, whereas compound 5 was identified from the leaves of S. gigantea but not from the roots. The bioassay-guided isolation involved thin-lay

SUBMITTER: Baglyas M 

PROVIDER: S-EPMC12471146 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature