Genome Sequencing and Comparative Genomics of the Hyper-Cellulolytic Fungus <i>Talaromyces pinophilus</i> Y117.

ABSTRACT: Talaromyces pinophilus is a filamentous fungus with notable lignocellulose-degrading capacity based on enzyme activities and protein secretion potential, making it a compelling candidate for industrial biotechnology applications. In this study, we present the genomic characterization of the highly cellulolytic strain Y117, a domesticated variant of T. pinophilus, based on whole-genome sequencing and comparative genomic analysis with eleven related strains. Comprehensive analysis of CAZymes, transcription factors, and secondary metabolite diversity in T. pinophilus strains revealed that the exceptional lignocellulose degradation capacity of Y117 is driven by its unique genomic architecture. Key genomic features that distinguish Y117 include (1) significant expansion of

SUBMITTER: Li Y 

PROVIDER: S-EPMC12471171 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature