A Detailed Study of Infection Following Custom-Made Porous Hydroxyapatite Cranioplasty: Risk Factors and How to Possibly Avoid Device Explantation.

ABSTRACT: Background/Objectives: Postoperative infection is a significant complication following cranioplasty procedures. This study aimed to assess infection risk factors and clinical outcomes in patients undergoing cranioplasty with custom-made porous hydroxyapatite (PHA) implants, with a particular focus on treatment strategies used to manage infections and avoid implant explantation. Methods: This retrospective multicenter analysis included 984 patients who underwent PHA cranioplasty as part of a post-market clinical follow-up. Clinical data included demographics, surgical characteristics, infection features, microbiological results, infection management strategies, and outcomes. Associations with infection risk and implant explantation were assessed using chi-square tests. Resu

SUBMITTER: Mannella FC 

PROVIDER: S-EPMC12471258 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature