Comparative Diagnostic and Prognostic Performance of SWI and T2-Weighted MRI in Cerebral Microbleed Detection Following Acute Ischemic Stroke: A Meta-Analysis and SPOT-CMB Study.

ABSTRACT: Background and Objectives: Cerebral microbleeds (CMBs) are increasingly being considered as potential biomarkers of small vessel disease and cerebral vulnerability, particularly in patients with acute ischemic stroke (AIS). Accurate detection is crucial for prognosis and therapeutic decision-making, yet the relative utility of susceptibility-weighted imaging (SWI) versus T2*-weighted imaging (T2*) remains uncertain. Materials and Methods: We conducted a systematic review and meta-analysis (SPOT-CMB, Susceptibility-weighted imaging and Prognostic Outcomes in Acute Stroke-Cerebral Microbleeds study) of 80 studies involving 28,383 AIS patients. Pooled prevalence of CMBs was estimated across imaging modalities (SWI, T2*, and both), and stratified analyses examined variation by de

SUBMITTER: Tan R 

PROVIDER: S-EPMC12471313 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature