Biomarkers for Early Detection of Cisplatin-Induced Nephrotoxicity.

ABSTRACT: Nephrotoxicity is a common complication during antineoplastic therapy, particularly when platinum-based medications are used. Early detection of this condition is crucial for improving risk stratification and management, thereby enhancing decision-making in kidney disease treatment. However, traditional biomarkers for renal assessment lack sensitivity in identifying early or subclinical damage, underscoring the need for novel and more precise markers. This study aimed to investigate the effectiveness of urinary KIM-1, clusterin, nephrin, and serum cystatin C in detecting nephrotoxicity associated with platinum-based therapies. A total of 43 patients with different oncological diseases participated in the prospective study, divided into two groups based on the nephrotoxic potential of the a

SUBMITTER: Dimov N 

PROVIDER: S-EPMC12471489 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature