Anti-Inflammatory and Neuroprotective Effects of <i>Undaria pinnatifida</i> Fucoidan.

ABSTRACT: Undaria pinnatifida fucoidan (UPF), a sulphated polysaccharide derived from brown seaweed, has attracted scientific and clinical interest for its wide-ranging anti-inflammatory and neurodegenerative properties. A growing body of research shows that UPF inhibits NF-κB and MAPK signalling pathways, reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), decreases ROS production, and suppresses iNOS and COX-2 activity, thereby mitigating oxidative and inflammatory damage in vitro. In vivo studies confirm these actions, demonstrating reduced systemic inflammation, promoted antioxidant defence, modulated gut microbiota composition, and improved production of beneficial microbial metabolites. In parallel, emerging evidence highlights UPF's neuroprotective potential, characterised by prot

SUBMITTER: Yang C 

PROVIDER: S-EPMC12471492 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature