Biomarkers in Pediatric Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Review.

ABSTRACT: Diagnosis of neuropsychiatric (NP) involvement in pediatric systemic lupus erythematosus (pNPSLE) remains challenging due to NP symptom heterogeneity, lack of specific clinical criteria and validated diagnostic biomarkers, and invasiveness of common diagnostic methods for CNS disease. Although some biomarkers have been identified in adults, their sensitivity, specificity, and clinical applicability in pNPSLE are uncertain. We performed a systematic review according to PRISMA guidelines to evaluate the current evidence on biomarkers associated with pNPSLE. We searched four databases using appropriate search terms for articles in English. After applying our selection criteria, we included 29 studies, from which we manually extracted relevant parameters, including study design, sample size, p

SUBMITTER: Sapountzi E 

PROVIDER: S-EPMC12471529 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature