Herbal Weight Loss Supplements Induce Metabolomic In Vitro Changes Indicative of Oxidative Stress.

ABSTRACT: Background/Objectives: The prevalence of obesity continues to rise globally, and with this an increase in the use of herbal weight loss supplements (WLS). At present, there is limited evidence to support the efficacy and safety of WLS, and there have been growing reports of adverse events associated with their use. We aimed to determine those WLS that caused toxicity in vitro and to use ¹H nuclear magnetic spectroscopy (NMR) to examine the metabolomic changes induced by these WLS in human hepatic and intestinal cells. Materials and Methods: This study used in vitro methods and ¹H NMR spectroscopy to analyse the metabolomic changes in vitro of WLS available for purchase in Australia. Ten WLS were selected, nine WLS caused significant toxicity in HepG2 hum

SUBMITTER: Davies EC 

PROVIDER: S-EPMC12471570 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature