C-Reactive Protein for Early Diagnosis and Severity Monitoring in Melioidosis: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Melioidosis, caused by Burkholderia pseudomallei, is a serious infectious disease in Southeast Asia and northern Australia. Methods: We systematically reviewed observational studies measuring C-reactive protein (CRP) in laboratory-confirmed melioidosis for diagnosis, severity assessment, or outcome evaluation. PubMed, Embase, and Scopus were searched up to May 2025. Data were pooled using a random-effects model; heterogeneity was quantified (I²). Results: Seven studies (n = 451) were included. The pooled mean CRP level in melioidosis was 74.37 mg/L (95% Confidence Interval [CI], 32.76-168.83; I² = 99.1%), considerably higher than healthy reference values (<10 mg/L). Conclusions: CRP is consistently ra

SUBMITTER: Phongphithakchai A 

PROVIDER: S-EPMC12471701 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature