Driving Down Mortality: A 12-Year Retrospective Cohort Analysis of Mechanical Power and Driving Pressure in Ventilated ICU Patients.

ABSTRACT: Background and Objectives: Mechanical ventilation, while essential, can precipitate ventilator-induced lung injury (VILI) due to excessive mechanical stress. Among respiratory mechanics, driving pressure (ΔP) has emerged as the most robust predictor of mortality, with mechanical power (MP) and tidal volume (TV), respiratory rate (RR), positive end-expiratory pressure (PEEP), and peak inspiratory pressure (P_peak) also potentially influencing clinical outcomes. This study primarily evaluated whether the implementation of a standardized Lung and Diaphragm Protective Ventilation (LDPV) protocol, designed to minimize ΔP, reduced intensive care unit (ICU) mortality. Secondary objectives included assessing the prognostic impact of MP, P_peak, TV, RR, and PEEP on mortal

SUBMITTER: Rahimi P 

PROVIDER: S-EPMC12471722 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature