The Impact of Statin Use on Sepsis Mortality: A Systematic Review and Meta-Analysis.

ABSTRACT: Background and Objectives: Statins are among the most prescribed medications globally, primarily due to their potent lipid-lowering capabilities. This systematic review aims to identify, synthesize and evaluate current evidence regarding the potential protective effects of statins on sepsis mortality. Materials and Methods: A thorough and comprehensive database search was conducted in PubMed and Cochrane Library until 30 January 2025. Randomized control trials (RCTs) and cohort studies evaluating the effect of statin use on sepsis mortality were included. Risk-ratios (RRs) and 95% confidence intervals (CIs) were calculated. Statistical analysis and forest plot generation were performed using RevMan 5.4. Risk of bias was assessed using the RoB-2 and NOS tools. Results:

SUBMITTER: Philippou C 

PROVIDER: S-EPMC12471783 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature