Molecular Epidemiology of Carbapenem-Resistant <i>P. aeruginosa</i> and <i>Enterobacterales</i> Isolates from Clinical Infections and Their Susceptibility to Ceftazidime-Avibactam.

ABSTRACT: The overuse of carbapenems has driven the rise of carbapenem-resistant Pseudomonas aeruginosa (CRPA) and Enterobacterales (CRE), against which ceftazidime-avibactam (CAZ-AVI) offers an alternative treatment. This study phenotypically determined resistance profiles of P. aeruginosa (PA), Escherichia coli (EC), and Klebsiella pneumoniae (KP) clinical isolates to CAZ-AVI and investigated molecular resistance mechanisms genotypically. A total of 394 PA, 90 EC, and 84 KP isolates were collected from the American University of Beirut Medical Center. Antimicrobial susceptibility testing (AST) and whole-genome sequencing (WGS) were performed on 30 isolates per species. Results showed that 100% of KP, 63% of EC, and 100% of PA isolates were carbapenem-resistant. A

SUBMITTER: Gerges JR 

PROVIDER: S-EPMC12471842 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature