New Marine Actinobacteria Strain, <i>Micromonospora</i> sp. SH-82: Characterization, Specialized Metabolites and Biological Activities.

ABSTRACT: The study of various microorganisms isolated from an Indian Ocean sponge, Scopalina hapalia ML-263, led to the selection of a promising Actinobacteria strain, Micromonospora sp. SH-82. Genomic analysis identified this strain as a new species, revealing the presence of 23 biosynthetic gene clusters (BGCs), some of which are associated with the synthesis of specialized metabolites such as polyketides deriving from polyketide synthases (PKSs). The strain was cultivated under favorable conditions for the production of bioactive molecules, resulting in the isolation and identification of seven microbial metabolites. Three of them are potentially novel, two erythronolides and one erythromycin, all characterized by a rare C10-C11 double bond. Some of these compounds also display aty

SUBMITTER: Le Loarer A 

PROVIDER: S-EPMC12471853 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature