Urinary ¹H-NMR Metabolomics Highlights MIIA (Microbiota-Immune-Inflammation Axis) Activation by Organic Mediterranean Diet.

ABSTRACT:

Background

While the Mediterranean diet is well-established for its health benefits, the specific influence of organic versus conventional food sources within this pattern remains underexplored at the systemic metabolic level.

Objective

This study investigated the metabolic effects of two matched Mediterranean diets, one based on organically produced foods (IMOD) and the other on conventionally produced equivalents (IMNOD), to assess the impact of food production methods on host metabolism and immune-inflammatory balance.

Methods

Twelve healthy adults completed a crossover dietary intervention including IMOD and IMNOD phases. Urinary metabolite profiles were assessed via ¹H-NMR spectroscopy across 42 compounds. Multivariate and univariate analyses evaluated

SUBMITTER: Di Renzo L 

PROVIDER: S-EPMC12471874 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature