Whole-Genome-Sequencing Analysis of the Pathogen Causing Spotting Disease and Molecular Response in the <i>Strongylocentrotus intermedius</i>.

ABSTRACT: Sea urchin aquaculture has experienced remarkable growth in recent years. However, this growth has been accompanied by increased disease prevalence. Notably, spotting disease has particularly severe impacts. In this study, we isolated the pathogen HZ-3-2 from 10 sea urchins with spotting disease, and it was identified as Vibrio splendidus through morphological observations, 16S rDNA sequencing, and whole-genome sequencing. Subsequently, experimental infection confirmed that V. splendidus (HZ-3-2) is the causative agent of spotting disease in this outbreak. The drug sensitivity confirmed the presence of drug resistance genes, such as CPR, QNRS5, and rsmA, which were identified in the genome. The tests indicated that V. splendidus was sensitive to va

SUBMITTER: Li S 

PROVIDER: S-EPMC12471893 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature