Metabolomic Profiling Reveals Distinct Signatures in Primary and Secondary Polycythemia.

ABSTRACT: Background/Objectives: The differential diagnosis between primary polycythemia vera (PV) and secondary polycythemia (SP) presents significant clinical challenges owing to substantial phenotypic overlap. This investigation utilized untargeted metabolomic approaches to elucidate disease-specific metabolic perturbations and evaluate the metabolic consequences of cytoreductive therapeutic interventions. Methods: Plasma specimens obtained from PV patients (n = 40) and SP patients (n = 25) underwent comprehensive metabolomic profiling utilizing liquid chromatography-mass spectrometry (LC-MS) platforms. Multivariate statistical analyses, including principal component analysis (PCA), were employed in conjunction with pathway enrichment analyses to characterize disease-a

SUBMITTER: Yıldırım M 

PROVIDER: S-EPMC12471915 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature