Development and Validation of a NEWS2-Enhanced Multivariable Prediction Model for Clinical Deterioration and In-Hospital Mortality in Hospitalized Adults.

ABSTRACT: Background and Objectives: Early identification of patients at risk of clinical deterioration is essential for optimizing therapeutic management and improving outcomes in general medicine wards. The National Early Warning Score 2 (NEWS2) is a validated tool for predicting patient worsening but integrating it with additional clinical and demographic data can enhance its predictive accuracy and support timely clinical decisions. Material and methods: In this retrospective cohort study, 2108 patients admitted to the general medicine department of the University Hospital of Siena were analyzed. Logistic regression models incorporating NEWS2 alongside key clinical variables-including age, presence of central venous catheter (CVC), and functional status measured by the Barthel Inde

SUBMITTER: Lo Conte S 

PROVIDER: S-EPMC12471953 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature