Synthesis and Characterization of Curcumin-Polycaprolactone Block Copolymers for Biomedical Applications.

ABSTRACT: Polycaprolactone (PCL) is widely utilized in biomedical applications such as tissue engineering and drug delivery; however, its limited bioactivity remains a key challenge. In this study, bioactive curcumin-polycaprolactone block copolymers (MCP) were synthesized via ring-opening polymerization of ε-caprolactone and maleic anhydride modified curcumin. The resulting MCP was characterized using FTIR, ¹H NMR, UV-Vis spectroscopy, and differential scanning calorimetry (DSC). It demonstrated enhanced antioxidant activity, UV-blocking capacity, and electro spinnability compared to PCL. Electrospun MCP films exhibited improved biocompatibility and promoted fibroblast migration. Furthermore, composite films incorporating MCP into a PVA matrix with and without copper or iron were evaluat

SUBMITTER: Wei Q 

PROVIDER: S-EPMC12471959 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature