Mutations in the Ferric Uptake Regulator Gene (<i>fur</i>) Suppress the Bacitracin Sensitivity of a <i>Helicobacter pylori fapH</i> Deletion Mutant.

ABSTRACT: Helicobacter pylori uses a cluster of polar flagella for motility. H. pylori FapH forms a ring-like flagellar motor accessory associated with the outer membrane. A H. pylori ΔfapH mutant displays a motility-dependent sensitivity to bacitracin, an antibiotic that is normally excluded by the outer membrane, which suggests that FapH helps to maintain the integrity of the outer membrane during flagellar rotation. We report here that deletion of the ferric uptake regulator (fur) gene suppressed the bacitracin sensitivity of the H. pylori ΔfapH mutant. Depleting intracellular iron in the H. pylori ΔfapH mutant with the iron chelator 2,2'-dipyridyl similarly suppressed the bacitracin sensitivity of the strain. We postulate the altered

SUBMITTER: Rosinke K 

PROVIDER: S-EPMC12472139 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature