Metabolomics and Cytokine Signatures in COVID-19: Uncovering Immunometabolism in Pathogenesis.

ABSTRACT:

Background

This study aimed to analyze metabolic changes in blood samples from patients with confirmed COVID-19 to explore the correlation between metabolomics and cytokines in survivors and non-survivors of SARS-CoV-2 infection. Understanding the complex biochemical and immunometabolic mechanisms underlying SARS-CoV-2 infection is essential for elucidating the pathophysiology and virulence of COVID-19.

Methods

This study included 40 hospitalized COVID-19 patients and 40 healthy controls. Serum metabolic profiles were analyzed using ultra-high-pressure liquid chromatography-mass spectrometry (UHPLC-MS), and cytokine levels were measured using ELISA.

Results

Our study defined three clear metabolic phenotypes among survivors and non-survivors of COVID-19 compared with h

SUBMITTER: Banoei MM 

PROVIDER: S-EPMC12472153 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature