OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus <i>Talaromyces amestolkiae</i> HDN21-0307.

ABSTRACT: Six new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A-B (1-2), a novel oxime-functionalized azadiphilone analogue talarooxime A (3), a new phenylhydrazone alkaloid talarohydrazone E (4), and two new dipeptide compounds talarodipeptides A-B (5-6), were isolated from the deep-sea cold-seep-derived fungus Talaromyces amestolkiae HDN21-0307 via OSMAC approach. Compound 1 is the first natural naphthalene compound with cyano groups. Compound 3 represents the first natural product containing an oxime-functionalized azadiphilone scaffold. Their structures and absolute configurations were elucidated through spectroscopic data analysis and quantum chemical calculations. Notably, compound 3 demo

SUBMITTER: Huang X 

PROVIDER: S-EPMC12472177 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature