<i>Acanthospermum australe</i> Extract Inhibits the Chaperone Activity of <i>Plasmodium falciparum</i> Heat Shock Protein 70-1.

ABSTRACT: The resistance of malaria parasites towards the current antimalarial therapies continues to fuel the search for new antimalarial drugs, preferably from natural sources. This study aimed to investigate the potential of the dichloromethane extract of Acanthospermum australe to inhibit Plasmodium falciparum heat shock protein 70-1 (PfHsp70-1). The plasmodium lactate dehydrogenase (pLDH) assay was used to determine the antiplasmodial activity of the crude extract against the chloroquine-sensitive P. falciparum strain 3D7. The inhibitory effect of the plant extract on the chaperone activity of P. falciparum heat shock protein 70-1 (PfHsp70-1) was determined using the ATPase, thermally induced luciferase and malate dehydrogenase (MDH) assays. The extract

SUBMITTER: Koza NA 

PROVIDER: S-EPMC12472254 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature