Imaging and Microorganism Analyses of the Effects of Oral <i>Bifidobacterium breve</i> Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.

ABSTRACT:

Background

Oral probiotic intake is suggested to have positive effects on skin. We aimed to elucidate the effects of oral Bifidobacterium breve M-16V intake on skin by analyzing facial images, the skin myco/microbiota, and the gut microbiota.

Methods

We conducted a randomized, double-blind, placebo-controlled study in Japan. Healthy women aged over 30 years were randomly allocated to either the B. breve (1 × 1010 colony-forming units (CFU)/sachet, two sachets daily) or the placebo group and consumed the corresponding study food for 12 weeks. Facial images were taken at weeks 0, 4, 8, and 12 using VISIA evolution. Stool and skin samples were collected at weeks 0 and 12. The primary outcome was the change in the total VISIA score from baseline.

Results

A t

SUBMITTER: Nishikawa Y 

PROVIDER: S-EPMC12472256 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature