Immunization with mRNA-LNPs Encoding <i>Ornithodoros</i> Argasid Tick Antigens Induces Humoral Immune Responses and Tick Resistance.

ABSTRACT: Argasid ticks Ornithodoros erraticus and Ornithodoros moubata are major vectors of zoonotic pathogens, including the African swine fever virus and relapsing fever Borrelia spp., and their control is essential to reduce disease transmission. In this study, we evaluated the immunogenicity and protective efficacy of four Ornithodoros tick antigens formulated as mRNA-lipid nanoparticles (mRNA-LNPs): OeSOD, OeTSP1, OmPLA2, and Om86. Rabbits were immunised with three doses of each mRNA-LNP construct, and immune responses and tick biological parameters were assessed following infestation with both tick species. All mRNA-LNP constructs induced antigen-specific IgG responses that recognised native proteins in tick saliva and midgut extracts. Vaccination resulted in signi

SUBMITTER: Oleaga A 

PROVIDER: S-EPMC12472351 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature