Anti-Atrophic Effects of Dichotomine B from <i>Stellaria dichotoma</i> During Starvation-Induced Skeletal Muscle Atrophy.

ABSTRACT: Muscle atrophy is defined as reductions in muscle size and function and represents a critical concern affecting elderly populations, immobilized patients, and individuals following specific dietary regimens, such as fasting and low-protein diets. This study investigated the protective effects of Stellaria dichotoma root extract and its isolated bioactive compounds during muscle atrophy using both in vitro and in vivo experimental models. First, S. dichotoma root extract prevented dexamethasone (DEX)-induced atrophy in C2C12 myotubes. Through systematic solvent partitioning and resin chromatography, five compounds (1-5) were successfully isolated from the n-butanol fraction. Dichotomine B (2) was identified as the most abundant and bioactive constit

SUBMITTER: Kim JY 

PROVIDER: S-EPMC12472366 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature