Formation of Racemic Phases of Amino Acids by Liquid-Assisted Resonant Acoustic Mixing Monitored by Solid-State NMR Spectroscopy.

ABSTRACT: Mechanochemistry has become a fundamental method in various sciences including biology and chemistry. Despite its popularity, the mechanisms behind mechanochemically induced reactions are not very well understood. In previous work, we investigated molecular-recognition processes of molecules capable of forming racemic phases in ball mill devices. Solid-state nuclear magnetic resonance (solid-state NMR) was used as the key technique to analyze such events. We now extended this study and focused on mechanochemically induced racemic-phase formations of two representative amino acids, alanine and serine, in a resonant acoustic mixer. The data reveal the importance of adding small amounts of solvents (here water) to facilitate the underlying solid-state molecular-recognition processes. The role

SUBMITTER: Hendrickx L 

PROVIDER: S-EPMC12472410 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature